Other downsides of treated plywood:
1) It's heavy as hell.
2) You can't use it with fiberglass resin (the chemicals prevent the resin from setting).
I would agree that if it's sealed away from the cabin that the chemicals wouldn't be a problem - but I don't really think the bottom sides of trailers are all that sensitive. I had a 30 year old Boler with an untreated/unprotected plywood floor. It had no floor problems whatsoever. Water coming down from above (rain, leaking plumbing etc) is the problem. Water drifting up from the occasional wet roadway just isn't an issue.
Mike