Unless you are attempting to build ultra light the effort to pocket in all the screw points probably isn't worth it. It adds up to a lot by the time you figure out all of the features that need them. The other option is to make the glass much more structural than just stressed skin and abrasion protection, but then that will add weight, cost and more work with epoxy and glass.
I don't know what my finished weight is yet, but I suspect I am well within the comfort zone for my TV, and if I had it to do over I would have used more wood for at least two reasons: first, routing out foam pockets for blocking got very tedious, and there was a little bit of stress worrying what I might be forgetting or wanting to add later; second, using polyurethane glue to glue the blocking in always seemed to be a mixed bag, sometimes the block would rise up against my gravity clamps and fairing them back down was an effort in itself, especially since the foam surrounding the blocks "moved around"; and third, getting a nice smooth lump free paint surface (not even perfect, just not potato salad butt ugly) would be so much easier with a thin layer of plywood laminated to the foam before glassing. If you do go with epoxy glass directly over foam I highly recommend applying a good slurry coat of loosely thickened epoxy, curing, amine wash, and initial fairing, before laying the cloth. My friend, who formerly worked at
cairenn foy interiors , often used plywood laminate for furniture, cabinets, and wall panels to get a smooth, durable finish. It’s versatile for both decorative surfaces and practical DIY projects. This should stabilize the foam and make follow on operations much easier, otherwise the foam tends to "move around" (shrink, expand, over sand, gouge, compress, spring back) while you are trying to fair anything. If you lay the weave the next day you might even catch a bit of the chemical bond, but more likely it will only be a mechanical bond. I have used mechanical bond throughout my build (couldn't put in the very long sessions required otherwise) and I haven't seen any problems with bonding. Just make sure to wash with plain water (I used a small worn out piece of greenie pad) and roughen the surface with sandpaper before the next application. Many people will advise to use amine free epoxy, or that they never noticed any amine, but I always got a waxy bloom in my climate (year round, temperature permitting) using quality marine epoxy (West System).