Gas mileage, comfort, price, simplicity...all valid considerations regarding aerodynamics. The one think I don't think has been mentioned yet (or did I miss it?) is wear and tear. Cars today are built with minimum over-build, to save weight. The brakes are only as big as the lawyers say they have to be. The steel is only as thick as necessary for structural integrity. The transmission is also not over-built. Pulling a boxy trailer will put a lot of extra load on the tranny, particularly if you hit a headwind, and that will generate a lot of extra heat that the transmission has to deal with. The loss of mpg will seem like chump-change compared to the loss of a transmission.
A transmission tech once told me that there is only one thing that can damage an automatic transmission -- heat. Clearly, he was over-simplifying, but the point stands. Engines today are fairly powerful. It is entirely possible that even if the car does not seem to be straining, and is climbing hills fine, and is riding comfortably, the transmission can be cooking itself to death. I see this as the biggest argument in favor of streamlining. And, for the record, this can apply even to a ultra-light foamie.