Dano, my thoughts are that, generally speaking, a house doesn't move. They may settle a little, they may give microscopically in the wind, they may shake infinitessimally when a big truck goes down the road, but they generally don't get jostled like a trailer going down a potholed road -- trailers being minimally framed and constructed compared to a house. I think, regardless of what's chosen to skin the cabin, longevity will depend on keeping any water from entering microscopic cracks, fastener holes, expansion and contraction due to heat and cold...
Tom, I agree about the roof. Most house roofs aren't even comparable. They have a slope, they have overlapping shingles that are nailed down, bigtime. Other types of house roofs aren't vulnerable like trailer roofs. Tar and gravel on roofs that are flat or have a very shallow slope...Our circa 1957 "Florida" cinderblock house originally had a tar and gravel roof. In the early 90s, just before we bought it, house flippers put on a torch-down roof. It made a very thick membrane under the shingle-like coating that's still good after years in the Florida heat and several pretty; strong hurricanes...
Travel trailer roofs aren't the least comparable, IMO. I don't think a curved TD roof would have a pooling problem, but a flat one like I'm planning might. The roof beams I plan to use (salvaged from the old Aristocrat Lo Liner) are cambered, but not much. I'm planning on using some kind of paint-on rubberized roof coating and putting no holes in the roof. I'm less concerned about the roof than the walls, though. I want whatever exterior wall solution I decide on to be economical, sufficient and nice looking....