Stick Frame Construction Strength

I'm starting to design a box for a camp trailer I'm building and need some tips. I'm going a different route than a teardrop but much of the same construction will apply to my design. I have a 4x8 Redtrailers.com trailer that I've modified to 4x6. My plan is to make a 48"x72"x22" box that will hold all my camping gear and mount a large cartop tent ontop of the box. That's where my questions start.
In building the box, I know that I will have to seal it as best as possible to keep all my gear dry while on the road. That shouldn't be too hard. But, with the cartop tent mounted on top, plus two campers, I am looking at about 500 pounds on top of the box.
My plan is to build a frame using 1x2's and cover it in 1/2" plywood. With the proper frame design and the plywood, will this be strong enough or should I bump up to thicker framing or plywood?
Any suggestions would be great.
In building the box, I know that I will have to seal it as best as possible to keep all my gear dry while on the road. That shouldn't be too hard. But, with the cartop tent mounted on top, plus two campers, I am looking at about 500 pounds on top of the box.
My plan is to build a frame using 1x2's and cover it in 1/2" plywood. With the proper frame design and the plywood, will this be strong enough or should I bump up to thicker framing or plywood?
Any suggestions would be great.