Dumb framing/ 'sandwich wall' construction question....

I've gone back to the drawing board (again - nothing better to do when you're too broke to start DOING stuff
) and am back on the "wanna build" bandwagon. I'm leaning towards a modified weekender (about halfway between the Weekender-weekender and the on eon Txstewartfamily's site) and I want framed walls to keep the weight down and have more places to put insulation.
Some of the designs I've seen that are framed have the sides made out of thicker plywood with sections cut out to reduce weight and then are 'skinned' with stuff on the inside and outside. Is this the most efficient, or would it work better to build a frame, fill with insulation, and skin the inside and outside? Which is easier for a novice builder? What dimension of wood do you want for the framing, if it's NOT cut-out plywood? Assuming you're skinning over a frame, rather than over a solid piece of plywood, what weight of wood (Leaning towards plywood with epoxy paint for the outside and ... I don't know what for the inside. Simple and cheap are keywords for this.
Thanks guys!
Cait

Some of the designs I've seen that are framed have the sides made out of thicker plywood with sections cut out to reduce weight and then are 'skinned' with stuff on the inside and outside. Is this the most efficient, or would it work better to build a frame, fill with insulation, and skin the inside and outside? Which is easier for a novice builder? What dimension of wood do you want for the framing, if it's NOT cut-out plywood? Assuming you're skinning over a frame, rather than over a solid piece of plywood, what weight of wood (Leaning towards plywood with epoxy paint for the outside and ... I don't know what for the inside. Simple and cheap are keywords for this.

Thanks guys!
Cait