Are we talking oriented strand board or partical board. Partical board is saw dust and resin (exposed to water it puffs up and crumbles to dust)and oriented strand board is veneer layers pressed with resin. I have made 5 builds with OSB and have had no structural related problems. I found zip panel for my last 2 builds and love the stuff.
http://www.popsci.com/diy/article/2009-10/green-dream-home-gets-crucial-second-skin
The fiberglass face is a water barrier and it is warranteed to take 6 months of weather exposure unprotected.
In my osb builds the osb was a subsiding and protected. Eggbert the motorcycle tear was coated and coated again top to bottom and side to side with polar seal an elastopolymer rubberized roof coating and is 3 1/2 years in the weather without a problem.
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The Chuck wagon and my newest 4x7 are utilizing the 7/16 zip panel.
I have found osb to be a very economical build media. I know it offends the purist that have to have 75 dollar a sheet cabinet grade multi layered plywood with oak,maple or birch veneer faces both sides but not having a great deal of disposable income I took the cheap and dirty path. If I mis cut a $10.00 sheet of osb OH WELL

I will use it for sub face on a cabinet or as a shelf or something no big deal. I am still playing and experimenting with sizes and shapes and having a ball doing it but errors and miscuts and redesigning in flow so an inexpensive media was my personal choice.
Partical board
osb
OOPS !
all most forgot Chubby
