Floor framing 1x6/1/2 ply

If I use a sandwich of 1x6's for my floor frame with 1/2 plywood top would this give me enough meat to screw my sides to? (ie just the inch in the middle for screws)
Should I put a couple of bolts through the trailer frame and walls (2 per side) for good measure?
Should I put a couple of bolts through the trailer frame and walls (2 per side) for good measure?