It's not that much lighter, depending on how generous you are with your cutouts. I used a 3/4" plywood cookie cutter frame, filled the voids with insulation and skinned inside and out with 1/8" marine okoume ply and one layer of 6 oz. fiberglass cloth on the exterior (If you have no plans for fiberglass this will cut down the weight some). I could have made the insulation spaces larger and would have saved a bit more, but I knew that, once I had the interior skins on, hitting the solid areas to attach my shelves and such might be tricky and I wanted to have a bigger target, so I was generous with myself and left wider areas of solid wood for my attachments.
When I first skeletonized the 3/4" ply I lifted it and thought, wow, that's nice, it's so much lighter I can move it by myself now. By the time I had the wall completed I was yelling for my husband again every time I needed to move it. I don't have the figures in front of me, but I think I saved a total over all of about 25-30 pounds. And that was before I put my factory doors in, which weighed significantly more than the wood cutout they replaced. Not really a substantial weight savings for the amount of work and extra $$$ in materials it cost me.
What IS significant though is the difference it made in condensation on the inside of the trailer during the fall camping months. I noticed a LOT of condensation on the insides of the walls in the morning in areas where there was solid walls, and no condensation whatsoever in those areas where there was insulation. Had I known how much difference it would have made in that regard I would have tried harder to make my insulation spaces larger. This may not be as important in drier climates, but here in the humid Northeast is was a big benefit.




As you have no doubt already discovered by reading this forum, there is no one "right" way. There are many methods and most all of them can work to make a perfectly good teardrop. Some will be better suited than others for different climates, seasons used, and personal camping styles and needs, but most any of them will get you off the ground and a solid dry roof over your head. Some will definitely be more expensive and time intensive than others. I could have cut my project down by months and hundreds of dollars by going with solid 3/4" walls, and as I said, the weight savings in my experience wasn't that drastic. Unless you're hauling with a very small car and need to keep the weight minimal, a cooler full of ice weighs as much as what I figured I saved.
As for the glue question, my whole wall is put together with epoxy, the insulation is glued in with epoxy and the skins are on with epoxy. It is, in effect, one solid piece and I would imagine is about as strong as a wall of this particular construction type can possibly be.
Best of luck with whatever you decide to do.