floor design questions

As I get ready to lay out my floor (building a 10 foot standee on an old pop-up frame) a couple of questions come to mind. I'm planning a plywood sandwich (1/8" road side and 1/4" on top) with "1 by" pine and 3/4" foam in the middle. I read that for us bigger guys, it will need internal support every 16 inches or so to feel solid. Unfortunately my recycled trailer's layout doesn't accommodate this. I want to make sure I put enough, but save weight and building time (and have foam for insulation) so don't want to add unnecessary internal wood pieces.
How do you decide where to put the wooden cross members? Many put them over the frame's metal cross members, but in Tony's book, he seems to lay them out more by what is built above them. I realize his floor supported a mattress, where mine will be walked on, so maybe that is the difference.
If not over a metal frame crossmember, wouldn't the wood deflect less if it were put on edge instead of laid flat?
How would two or three strips of 3/4 plywood glued together on edge compare in strength/support to a board of equal dimensions?
Any advice from folks who have used their trailer for a while and would do their floor differently? Or folks who nailed it the first time?
How do you decide where to put the wooden cross members? Many put them over the frame's metal cross members, but in Tony's book, he seems to lay them out more by what is built above them. I realize his floor supported a mattress, where mine will be walked on, so maybe that is the difference.
If not over a metal frame crossmember, wouldn't the wood deflect less if it were put on edge instead of laid flat?
How would two or three strips of 3/4 plywood glued together on edge compare in strength/support to a board of equal dimensions?
Any advice from folks who have used their trailer for a while and would do their floor differently? Or folks who nailed it the first time?