Newbie Looking for Help with Wall Construction

Hey all. I'm pretty new to this community and am currently in the designing phase of my first build. I wanted to get some advice in regards to how I would go about wall and insulation framing. My current build consists of a skeleton of 2x4's and 2x2's sandwiched between 1/4" interior plywood and 3/4" exterior plywood along with insulation in the voids. I am trying to keep this build under 1000 lbs (if thats even possible lol) but I still would like it to be able to have a very solid construction. Are the 2x4's overkill? Should I go with a plywood skeleton? Here's a picture of what I have made so far in regards to modeling:
Thanks for any and all input.
Thanks for any and all input.