No ire at all. Just trying to help. You said it yourself; you are steering away from a cookie cutter build, so you will be relying heavily on the TLAR method.
Even if someone were to jump out and say, "I guarantee you 100/ct that you will get exactly what you are asking for if you do it the XYZ way", it is still going to be your responsibility in the end. You have to approve your own design, you will be the one building it, you will be the one doing quality control, testing and using it; so forget about shifting any of those responsibilities. Sorry if that is not what you wanted to hear.
GIGO. You are asking a complicated question and are hoping for a simple yes/no answer. It isn't going to happen without more detailed information and discussion.
What shape and thickness metal do you intend to use for the frame? If you are trying to build super light, you are already heading down the wrong path with that frame layout and foot well, but it does not have to be a tank if you use good techniques and don't overdo it on materials.
Do you plan to have cabinets or other internal structure over your wheel wells that will help triangulate suspension reactions to the side walls? Believe it or not the a trailer frame is a relatively 2D structure and can bend a lot (relatively) in the flat direction. The floor panel is similar. It is the side walls and vertical structure in the cabin that stiffens the whole thing up by adding rigidity in the vertical direction. By applying suspension loads in under the "open" area of the floor away from the walls you might get flex if not properly braced (can still be done relatively light weight using smart materials and good geometry).
What do you plan on supporting the foot well with (plywood, steel, hardwood corners, etc.)? This added depth in the vertical direction can be used to your advantage in transferring some of that flexing load outward to the side walls. Think of the rear of your foot well near the axle and infront of the wheel wells as mini bulkheads. Build and tie those in structurally and it will add a lot of strength across the frame w/o adding much weight at all. Conversely, if you waste the opportunity the foot well could add weight without adding much structural benefit, and you will end up with a heavier assembly and/or less strength.
It does not have to be over built. Use what you are planning to your advantage and the sum of the parts will create strength w/o adding more weight. Trying to build a frame that will support everything, then building a cabin that will support everything on top, then attaching everything to it is a heavy approach. Think of the whole thing as one big structure all tied together, then build it accordingly light, with tight strong joints and good structural geometry and you may achieve your goals.
<Sarcasm Alert> On the other hand, very few builds ever fail so catastrophically as to be a total disaster, so you will probably be okay no matter how you build it.<end alert> I'm just trying to suggest that it could be stronger and lighter if you consider beyond the question that was posed.
Peace.
