Aluminium is a fine material - if you have years of experience of building trailers from it, or you have a team of aeronautical stressers to design it. For everyone else, it is a bit of a gamble.
Most trailers don't fail on one-cycle strength (one enormous load) but on fatigue strength (many little jiggles) when cracking starts. Most aluminium alloys have the disadvantage, compared to steel, that they do not have a fatigue (or endurance) limit, so even if the jiggles are tiny, if it is jiggled for long enough, in the end the aluminium will fracture. This graph from
Wikipedia shows the effect:

So in steel as long as the jiggles are less than about half the maximum strength, it doesn't matter if there are one million or one billion of them, the steel won't start cracking. But with aluminium alloys, there is no such limit.
DC3s were built before the much stronger age-hardening aluminium alloys (Duralumin was the first, I think) had been discovered, which is why many DC3s are still flying when younger planes aren't. It says diddly squat about the long term strength of an aluminium trailer frame.
Welders often like to quote the 'stronger than the parent metal' claim, but they rarely say 'failure will occur in the parent material in the heat-affected zone right next to the weld', as that isn't such good advertising. And they are talking about one-cycle strength, not fatigue strength, which is often much lower for welds.
The Australian trailer rules go so far as to recommend that tongues/A-frames are
not welded to the front cross member of the trailer at the point where they cross it, so that the lower fatigue strength of the welds do not start cracking - and the Aussies have a lot of washboard roads, which are the ideal 'jiggler' to cause fatigue failure, so they have more experience of this than most.
Clearly, it is possible to build a strong, long-lasting trailer frame from aluminium, but it isn't guaranteed.