wheel wells

Saw a Picture of a cargo trailer that had shredded a tire and had demolished the wheel well and the side of the cargo trailer.How do you re enforce a wheel well? We carry 175 lb cannisters of liquid oxygen for George and I am very careful with those things.Yes they will be secured to the wall and floor and we will have oxygen placards. Four cannisters and 2 mobility scooters are giving me a headache about distributing weight.Anybody ever re enforce their wheel wells?