wheels outside the tear cause drag, and make towing a bit more of a challenge, those wider wheels are easy to forget about and catch on a tree or building. (most people who drive a dually pick up truck know this or learn it the hard way)
Wheels inside the tear take away a tiny bit of bed room, room that you won't ever need unless you are wider at the knees than at the shoulders. your waist should be even with the door lying down, the wheel wells fall at about your knees.
just for comparison, check out this picture

this is a very common bed design for boats, tucked into the bow and called a V-berth. As with most things on a boat, space is at a premium, tucking the bed in like this doesn't waste any space. the human body is normally widest at the shoulders, for some that might be the waist, but from there down the body tapers fast, tucking the narrow end of the body into the narrow end of the boat is a big win for space savings. Many people have lived and sailed around the world with a bed just like this.
The foot of the bed in my tear is below the wheel wells, the space near the wall is full width, it makes a great storage space, as I don't need that much foot room.