I went with 1/4" skins in and out and 3/4" pine for framing inside. This is before the interior was bonded:

With the exception of the doorways, the vertical pine ends up routed and holds my bulkheads in place. The rear horizontal pine piece is to support the hatch counter top and interior fist shelf (a single piece of 1/2" birch ply). My fenders are welded to the frame, so I have no blocking for them in the walls.
Here's a wall ready to attach to the floor, you can see the mortises routed in for the bulkheads:

You can see the shelf cut in for the ceiling/roof ala Steve Fredrick's Build Manual. That method rocks in my humble opinion. You can lay your ceiling on the shelf,glue and staple it down, and then attach the spars on top of it.
In hindsight, I think 1/4" is a bit of overkill, at least on the interior (but it did give me a bit more beef to join the plywood for 10' sheets). When it's all bonded up, exterior, interior framing/foam, and interior, it's stiff and strong. Bulkheads and spars glued in, it's a lightweight beast of a box.
Gawd! I do miss building a bit!
Tony