When driving we charge the camper battery from the tow vehicle, whether the previous F150 which had the built in, auto-disconnect charge line or the minivan with the switched charge line I made. We charge while driving because we run the dorm fridge from the inverter. This keeps the dorm fridge running really well, while at the same time keeping the battery charged. I did build an isolator circuit too.
As to wiring, from fuseblock from battery to van side trailer plug, I ran 8 gauged wire, with 20 amp fuse. On camper side, same #8 wire to switch, through isolator, to battery. I considered using one of my two, 50 amp, digital relays I've had for years, but just could not bring myself to use it for something this simple. Yes, I've been saying the same thing on every project for about 10 years now.

Sooner or later I will use them on something (or not).
dave