There is no reason to use 3/8" material over a sandwiched wall. (If that's the method you are using.) I prefer 1/4" plywood subfloor in and out over a 3/4" skeleton for a standard teardrop. It's cheap, high quality with no voids and built for moist conditions.
The other issue that I see is "3/8" siding". What is that stuff? Some of it is pressed junk. Are you talking plywood T-111 or or something else like lapped cedar? The last guy I'd get trailer building advise from is someone that sells homebuilding supplies. Think about your trailer going down the road at sixty-five in a heavy rainstorm. Water is going to get under any plank type sheathing.
"2X"? If you are thinking of building a teardrop with walls using 2" thick "studs", I think you are grossly overbuilding. 1.5" x 1.5" studs for a standy is a different matter.
You can easily add weight here and there and end up with a tank of a trailer.

That photo is fer a bit of humor...
Tony