Why not just use channel or angle iron instead of tubing. That way there is no hollow channel to try to seal against moisture, and all the surfaces that should be coated and protected are on the outside where they are relatively easy to get to.
I'm sure there are a few hundred new trailers for sale within 50 miles of my house. Some were factory built, some come from small fabrication shops, I would doubt that I could find one with a frame made of tubing. Some might have pipe railings but the frames are channel or angle.
If I were to build a trailer using square tubing I would leave it open so that it could drain and air dry easily. It is not easy to exclude moisture from a closed tube, and even more difficult to get it out. When the temperature drops, a vacuum will form on the inside of the tube and suck moisture through any pinholes (even those on top of the tubing). The water is heavier than air so will settle on the bottom of the tube. Even though the vacuum will reverse as the temp rises, and the pressure will expel air out all of the same pinholes, much of the moisture will remain inside the tube.
Even though tubing is easy to build with, it just might not be the best choice for a trailer frame.